The billionaire businessman Donald Trump was officially named the 2016 Republican Presidential nominee early on Wednesday.
Trump is scheduled to address the convention via remote from New York on Wednesday evening, but tweeted shortly after the vote.
"Such a great honor to be the Republican Nominee for President of the United States. I will work hard and never let you down! AMERICA FIRST!"
Trump ousted 16 mainly establishment rivals as his populist campaign caught fire among the Republican base, and managed to avoid a contested convention after hammering his final rivals Ted Cruz and John Kasich in the last primary races.
The real estate mogul is expected to formally accept the nomination in a speech to the convention on Thursday, before facing off against Democrat Hillary Clinton in the November election.
Trump was put over the top by his home state of New York. Four of his children joined the state's delegation on the convention floor for the historic moment and appeared overwhelmed with emotion.
"Congratulations, Dad, we love you," declared Donald Trump Jr.
"It's unbelievable. It's surreal. I'm so proud of my father," his eldest daughter and businesswoman Ivanka Trump, often described as his secret weapon, told CNN on the convention floor.
"He's the ultimate outsider and he did it. We are so proud of him."
The nomination of Donald Trump ended what had been a poor day for the Trump campaign. His team spent much of Tuesday fending off accusations that Melania Trump, the nominee’s wife, had plagiarised part of her Monday night speech to the convention from an address that Michelle Obama gave at the Democratic convention in 2008.